The Chemistry and Biology of Nitroxyl (HNO) Fabio Doctorovich, Patrick Farmer, Marcelo A. Marti
Publisher: Elsevier Science
Ity have spurred interest in the chemistry and biochemistry of nitroxyl (HNO). The Physiological Chemistry and Biological Activity of Nitroxyl (HNO): The Neglected, Misunderstood, and Enigmatic Nitrogen Oxide. It has the chemistry that may be relevant to the biological actions of nitroxyl. The chemical biology of HNO, is to determine the pharmacological and possible endogenous production of this species in vivo. The distinct biological properties of nitroxyl (HNO) have focused research regarding the chemistry and biology of this redox relative of nitric oxide (NO). It is clear that HNO possesses unique and a potentially important biological activity that is distinct from NO (and other nitrogen oxides). Department of Chemistry, Massachusetts Institute of Technology, Cambridge, CONSPECTUS: Nitroxyl (HNO) is a biological signaling. Its chemical reactivity and biological activity are still not completely understood.HNO donors show biological effects different from NO donors. Nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), shows a distinct chemical and biological profile from that of NO. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. The Chemistry and Biology of Nitroxyl (HNO): A Chemically Unique Species with Novel and.